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But drugmakers do not typically grant licences for top treatments like dolutegravir in countries like Colombia and Brazil, which both have high HIV rates but are considered upper-middle-income

Many commercial formulations contain higher concentrations

In hepatocytes, oxalate overload caused mitochondrial dysfunction and lipid accumulation by inhibiting the transcription of peroxisome proliferator-activated receptor and blocking mitochondrial FAO

Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis

consequently, astrocyte dysfunction can impair synaptic transmission, induce excitotoxicity, and cognitive and motor impairments (Dodge et al., 2013)