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It is necessary for the proper function of the mitochondria, the energy-producing structures in cells

It is widely studied in regenerative biology, tissue repair, angiogenesis, and gastrointestinal research models

(Increase in growth hormone receptor expression in tendon fibroblasts)

Moreover, amino acids, such as tryptophan metabolites, have been shown to function as a key class of immunomodulatory mediators capable of regulating immune homeostasis in MS (7983)

Probst et al., 2010

However, as the development and testing of remyelination-based therapies requires effective model systems with sustained demyelination and lack of complete endogenous remyelination, we conclude that 1 mM CPZ treatment of brain slice cultures is not a viable ex vivo model for these studies, however, could prove to be useful in acute demyelination studies, pending further characterization