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Methods Ethics statement Prior to any specimen collection, community consent was first obtained from village leaders

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Given that PI3K/AKT signaling regulates ELF3 expression, these findings support a model in which HER2HER3-mediated PI3K/AKT activity uniquely sustains the ELF3KRAS transcriptional program in KRAS G13D cells

Oxidative stress in angiogenesis and vascular disease

One group demonstrated that FGF21 increased bone resorption and decreased bone mass in mice (321), in part via induction of hepatic insulin-like growth factor binding protein-1 (IGFBP1) (322)