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Exogenous strigolactones promote lateral root growth by reducing the endogenous auxin level in rapeseed

Earlier genetic work on the related demethylase ALKBH5 complements this picture from a metabolic angle: ALKBH5 loss lowers lactate accumulation, curtails suppressive myeloid/Treg niches, and markedly augments anti-PD-1 efficacy in vivo

Anticancer activity Effects on carcinogen metabolism Inhibition of metabolic activation of carcinogens Some chemical carcinogens do not become active carcinogens until they have been metabolized by Phase I biotransformation enzymes, such as those belonging to the cytochrome P450 (CYP) family

In colorectal cancer, IGF2BP3 binds m 6 A-modified ABCB1 (MDR1) mRNA, stabilizes it, and triggers multidrug resistance

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In addition, MEK expression has some predictive value for TNBC patients overall survival (OS) and recurrence-free survival (RFS) following neoadjuvant treatment (89)