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Microbial diversity is fundamental to maintaining gut ecosystem homeostasis and overall host health, with its abundance and stability directly shaping the adaptability of the intestinal microecosystem and host physiological function

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The compound has been found to operate in the postrema and nucleus of the hindbrain solitary tract in order to both induce satiety and regulate appetite by acting on receptors found in the laterodorsal tegmental nucleus, ventral tegmental area, and the hypothalamus [1]

For the shRNA KD ChIP-seq data sequenced by Novogene, the raw sequencing reads were trimmed by Cutadapt and then mapped by Bowtie 2 with the --very-sensitive parameter

We further point out that there are there few patients in this study ( n = 7) who were on insulin, hence it is unclear if the observations described here extend to those in whom insulin insufficiency is severe

T-REX coupled with co-immunoprecipitation assays revealed that NCBP1-HNEylation caused no perturbation of the association between NCBP1 and ALYREF, PHAX or PRPF4 (Supplementary Fig