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doi: 10.3329/icpj.v2i2.13192 79 BhandarkarNSMouattPGoncalvesPThomasTBrownLPanchalSK

doi: 10.1016/j.bbi.2015.09.013 504 TanakaSKuratsuneHHidakaYHakariyaYTatsumiK-ITakanoTet al

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Observed responses in research settings are generally reported as mild and may include: Temporary injection-site irritation Redness or warmth sensations Skin-sensitivity variability Temporary blue-tinted discoloration beneath the administration area Localized irritation depending on dosage range, concentration, administration frequency, protocol duration, and individual sensitivity Research protocols commonly investigate daily administration ranges between: 12mg daily in standard research settings Up to 3mg daily in more advanced experimental protocols GHK-Cu is frequently explored in continuous or maintenance-style research structures and does not always require strict cycling protocols in moderate-dose experimental models

For example, PARP inhibitors sensitize ovarian cancer cells to ferroptosis by synergistically activating ATM/ATR and causing DNA damage [126]