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the body cant synthesize them endogenously

Several human cohort correlations together with basic/translational experimental data seem to confirm deep IGF1 implication, albeit with controversy, which might, in part, be given by experimental design leading to blurred result interpretation

We see the effect of this first hand in the clinic when patients report symptoms like feeling sluggish, depressed, having sleep problems and brain fog

For metabolism of NR, NRK1 is expressed in most tissues but is absent in the spleen and white adipose tissue, while NRK2 is only present in skeletal muscle, heart, and white adipose tissue (WAT) 40