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doi: 10.1186/1742-2094-8-94 135 StrawnJ

CPT1A , the rate-limiting enzyme in fatty acid oxidation (FAO) that provides an alternative energy source for the survival of cancer cells, plays a crucial role in metabolic adaptation in cancer pathogenesis (108)

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When the gut microbiota is disordered and the intestinal epithelial barrier is damaged, immune cells recognize a variety of bacterial components through pattern recognition receptors to recognize highly conservative pathogen-associated molecular patterns, leading to systemic and tissue-specific inflammation [345]

To mitigate the effect of NETs on DVT formation, we can minimize the formation of DNA and histones or secrete enzymes that break down or regulate NETs, such as the inhibition of PAD4 (231)

His legacy is therefore not tied to a single test or theory, but to a larger vision: that careful mechanistic science, applied to the most fundamental processes of biology, can illuminate the path to better health and longer life