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Menndez, S., Cepero, J., & Borrego, L

Structural basis for ragulator functioning as a scaffold in membrane-anchoring of rag gtpases and Mtorc1

Notably, BAs -mediated activation of FXR has been reported to suppress lipid peroxidation and inhibit ferroptosis

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Since the discovery of the genetic etiology of AS, extensive efforts have been devoted to the understanding of the underlying mechanisms of AS pathophysiology, mainly by utilizing the AS mouse model, which was shown to replicate multiple phenotypes of the human disorder [5, 6]

First, the current knowledge about the in vivo regulatory mechanisms of ferroptosis and cuproptosis pathways in HNSCC remains incomplete