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Crossing the BBB is particularly advantageous in malignancies such as glioblastoma multiforme (GBM), where diffuse infiltration and chemoresistance hinder surgical and pharmacological management

Both peptides stimulate angiogenic processes, which is why a theoretical risk of tumor growth is discussed

Taken together, these results suggest high selectivity of the small molecule 5-amino-1MQ analogue at pharmacologically relevant concentrations to NNMT-inhibition

The most consistently reported pathway involves VEGFR2 and the Akt-eNOS nitric oxide cascade

Common side effects include nausea, vomiting, diarrhoea, and constipation

First responder focus