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Sublingual B12 Supplementation: Pros and Cons Pros Easily absorbed: Sublingual B12 tablets are absorbed into the bloodstream through the mucous membranes when placed under the tongue

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AOD-9604 has a method of action that does not suppress appetite or absorption of food

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Both are easy to add to a routine lab order

As of June 2026, the FDA's December 2024 Pharmacy Compounding Advisory Committee evaluation concluded that the criteria weighed against placing AOD-9604 (free base) or AOD-9604 acetate on the 503A Bulks List, and AOD-9604 is currently listed as Nominated but Withdrawn from FDA Category 2