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PMID: 22354407

Existing studies have shown that some ZDHHC enzyme family members exhibit specific expression patterns in different tissues (252), however, the molecular mechanisms that regulate this tissue-specific enrichment remain to be elucidated in depth

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Normal aging is accompanied by a decline in cerebral metabolism, driven by impaired mitochondrial ATP production, increased reactive oxygen species (ROS), and decreased antioxidant defenses (Maldonado et al., 2023), and these deficits are amplified in ADRD compared to cognitively normal older adults (Patro et al., 2021