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For example, activation of the limbic and paralimbic systems, which are responsible for behavioral and emotional responses, are thought to contribute to distress signaling and complications of tinnitus, such as cognitive, mood, and sleep disorders, in some individuals

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Many commenters expressed their need for additional information so that interested parties would be able to accurately replicate Addendum J

Specify the Site of Injection: Clearly indicate where the injection was given (e.g., left deltoid)

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Consequently, their safety profile and efficacy in Crohn's patients, particularly those with active inflammation or stricturing disease, has not been comprehensively established