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In nucleophiles, the highest occupied molecular orbital (HOMO) is relatively high in energy, making it easier to donate electrons

doi: 10.15226/2378-1726/4/4/00163

Metallothionein-like gene from Cicer microphyllum is regulated by multiple abiotic stresses

Short chains of fewer than 50 amino acids penetrate cell membranes and tissue barriers more readily than larger protein complexes, enabling target specific receptor engagement with greater efficiency

Neurosci Bull 35:325

Specifically, the p-acetylphenylalanine (pAcF) was incorporated into each antibody, and the ketone group of pAcF was linked using linkers with an aminooxy functionality to enable oxime ligation