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and 82472668 to F.L.), the Jiangsu Province Natural Science Foundation (award nos

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The National Institute of Drug Abuse warns that street formulations confiscated by police initially reported as pure MDMA have been mixed with other agents such as cocaine, methamphetamine or bath salts, which can have extremely dangerous side effects and symptoms

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These effects are mediated through inhibition of the NF-B/NLRP3/caspase-1 and Bax/Bcl-2/caspase-3 pathways, alongside activation of Nrf2/HO-1, p-AMPK, and -Klotho signaling (Khallaf et al