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and MDRD study equations and to investigate which estimation approach provides more precise identification of patients with increased drug concentrations

2019;179(7):1483-1498.e1422

Disadvantages included high cost, slow time course, and ethical concerns

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The breakthrough for cagrilintide was applying the fatty acid acylation technology that made semaglutide viableattaching a fatty acid chain to a modified amylin analog backbone that prevents aggregation while enabling extended albumin binding