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Macrocyclic drugs and clinical candidates: what can medicinal chemists learn from their properties

Loren Pickart, der GHK 1973 erstmals aus menschlichem Plasma isolierte

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Selank is a synthetic heptapeptide analog of the endogenous immunomodulatory peptide Tuftsin (Thr-Lys-Pro-Arg), with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro

High doses beyond the typical daily requirement are avoided unless necessary, but there is no evidence of harm to the fetus from normal vitamin B therapy