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After 12 d of culture, the ALP activity in the -GP-induced calcifying VSMC group dramatically increased compared to that in the noncalcifying group, while TAU or LC treatment alone had no influence on the ALP activity in the noncalcifying VSMCs

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J Pineal Res 66(4):e12564 Wolden-Hanson T, Mitton DR, McCants RL, Yellon SM, Wilkinson CW, Matsumoto AM, Rasmussen DD (2000) Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat