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In these cases, evaluation helps determine whether topical support is appropriate or if medical treatment is needed

La deficiencia de vitamina B12 en la reduccin de la sntesis de ADN es explicada por la "teora del atrapamiento de folato como metil-tetrahidrofolato".(...) la metionina sintetasa no puede ser activada y el folato se queda como metil-FH4, lo que causa tambin un dficit funcional de folato

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