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When carbohydrate intake drops severely, this regulatory system can become impaired, leading to reduced conversion of T4 into the active thyroid hormone Free T3

Research suggests that the process of detoxifying these synthetic hormones causes more free radical production, drawing down the bodys natural glutathione levels leaving the body more susceptible to oxidative damage

Binding to these receptors causes different effects depending on the tissue type, e.g

Patients with Charcot-Marie-Tooth (CMT) disease can have increased susceptibility and severity of CIPN, especially in the setting of CMT1A and vinca alkaloids 8487