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Mutations in IDO2 are common in the population, but the elevation in tryptophan, likely triggered by multiple factors such as stressors and pathogens, is rarer and is the potential cause of ME/CFS

Repeat testing or additional evaluation may sometimes be recommended

Additionally, alignment to the central helical Z -axis and a simple morph of the global basal and activated models show that the large conformational change is possible in the filament with fewer clashes when the CD moves in concert with the RDs (Supplementary Fig

Non-pharmacological interventions include medication adjustment

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