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The synthesis of nanozymes is relatively straightforward and well-established, with chemical synthesis, solution synthesis, and thermal decomposition being among the most commonly used methods

In order to quantify this visual phenomena, brightfield images were converted, thresholded and analyzed using ImageJ ( Additional file 1 , Figure S2 ), where surface contrast is given as a proxy for apical muco-ciliary uniformity

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In the SN neurons of PD, the expression of Nrf2 in the nucleus is enhanced, and the expression of its signature proteins NQO1 and HO-1 is upregulated, suggesting a brain protective effect mediated by Nrf2