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These observations provide a novel theoretical foundation for the treatment of OP via targeting the GM5-HT axis, indicating that suppression of gut-derived 5-HT biosynthesis may serve as a promising anabolic approach for bone health

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A compensatory response resulting from an increased level of acetyl-carnitinewhich reflects cellular acetyl-CoA, a potent allosteric activator of PCwas reported in both INS-1 cells and isolated islets with moderately lowered PC [36]

Consistent with this, our findings revealed that the number of PGP9.5 positive cells markedly reduced after Loperamide administration in the group that received sham-SNS treatment