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Theyre also stain-resistant and require no additional maintenance beyond regular oral hygiene

Expectation-setting at the first consultation is most of the clinical work, because remodeling effects unfold over weeks to months rather than days

(StatPearls Publishing, 2023)

Hormonal changes can trigger overproduction of melanin in the body, leading to large areas of darkened skin

Strategies such as combining copper ionophores with ferroptosis inducers, or superimposing DSF/Cu regimens on a background of GSH depletion or p53 activation, could overcome resistance to single-death modalities and deliver a potent ferroptosis-cuproptosis double punch to OSCC