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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Acta Haematologica 2009;122(2-3) 155-164 70

FOXO1 activation leads to the upregulation of both C/EBP and ATF4, which then coordinate to enhance the transcription of target genes, including ChaC1

41 This means that exclusively blocking IL-23p19 results in more direct and stronger inhibition of inflammation with no diverse effects on Th1/Th17 regulation