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Superoxide anion react with cytosolic hydrogen ions to produce perhydroxyl radicals (HOO )

Optimal methylation is a vital and necessary process that occurs in various chemical pathways involved in detoxification, cardiovascular, neurological, eye, muscle, bone, and reactive oxygen species form through oxidation

In conclusion, the present review provides a comprehensive overview of the potential therapeutic targets afforded by ferroptosisassociated pathways in stroke, offering new insights into how ferroptosis may be exploited in the treatment of stroke

Oxidative Stress/Redox Homeostasis Reactive oxygen species (ROS) are free oxygen radicals such as superoxide , hydroxyl radical (OH - ), and hydrogen peroxide (H 2 O 2 ) formed by reduction-oxidation (redox) reactions

GSSG reduction occurs at the expense of NADPH, produced from the pentose phosphate pathway (PPP) from glucose oxidation

L-Glutathione is a naturally occurring antioxidant composed of three amino acids and is known for its ability to help neutralize free radicals and protect skin from environmental stress