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When the Wnt pathway is activated, it binds to LRP5/6 and Frizzled receptors to form a complex, which stimulates the cytoplasmic transcriptional regulator -catenin to enter the nucleus and bind to members of the Lef1/Tcf family of nuclear proteins to activate the transcriptional expression of downstream target factors, such as Runx2, C-myc and other transcriptional expressions

DOI: Published: Publisher Name: Humana Press, Totowa, NJ Print ISBN: 978-1-60761-755-6 Online ISBN: 978-1-60761-756-3 eBook Packages: Springer Protocols

Jo CS, Myung CH, Yoon YC, et al

The NEM circuit comprises six circuits of related organs and body systems

E.OverholtzerM

In particular, branching within a structure may influence the solubility and stability, subsequently affecting the rates of degradation and absorption in biological systems