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Baricitinib is also a NAK inhibitor, with a particularly high affinity for AAK [40, 51]

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Ongoing and future clinical studies are expected to provide deeper insights into its mechanisms of action and expand its therapeutic applications

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RNA-Seq analysis provided direct evidence that LSC-Exo not only were able to efficiently reduce immune activation, maintain intracellular ROS homeostasis, and dampen inflammatory cytokine storm, but also alleviated pulmonary dysfunction in the hamsters by activating the antioxidant defense systems