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Description

Neuman, Samir S

2018;13:e0205158

Reactions to Allergies Some patients may have: Rashes on the skin Itching and hives Puffiness around the eyes or lips In very bad circumstances, anaphylactic shock can happen

Pharmacokinetics Mucolytics may be administered by nebulization or by direct instillation into the trachea via an endotracheal tube or tracheostomy

Biguanide-derived neuroprotective agent (metformin) To mitigate neuroinflammation and mitochondrial dysfunction in PD, metformin was encapsulated into PLGA, which were further coated with BV2 microglial cell membranes to enhance the targeting efficiency to neuroinflammatory sites (BV2-metformin-loaded PLGA) for intranasal administration 19