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In other urinary system tumors, transcriptomic studies centred on macrophages have revealed an immune-regulatory mechanism driven by lipid metabolism, which also supports the existence of similar metabolic-immune mechanisms in ccRCC (Wang et al., 2023

WizgierDMengYDasANaganathanVBlythFLe CouteurDet alThe association of dietary antioxidants and the inflammatory potential of the diet with poor physical function and disability in older Australian men: the concord health and ageing in men project

46,47 These effects are mediated by SIRT1 pathway activation, which optimizes mitochondrial function and autophagy, and by miRNA-dependent regulation (e.g., miR-146a targeting Nrf2/NF-B pathways), although the mechanisms vary across cell types and microenvironments

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Although substantial work still remains in identifying HDL binding proteins and receptors on the cell surface, HDL have been found to activate many signaling cascades through various receptors

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