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Guglielmo S, Cortese D, Vottero F, Rolando B, Kommer VP, Williams DL, et al

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At the same time, they showed that localization of L-K6 through clathrin-independent micropinocytosis, without disturbing the cell surface in the cells, causes nuclear damage and cell death, without significant disruption of the cytoskeleton and mitochondrial dysfunction [77]

Altered expression of the clock gene causes a loss of timely coordination among different brain areas, interferes with the regulation of basic cellular metabolic and homeostatic processes, and ultimately results in the disruption of connections among brain structures, ultimately leading to cognitive impairment and the characteristic chrono-disruption seen at the onset of early neurodegenerative diseases in patients

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Green, T., Dow, J., Ellis, M