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Talhada D, Marklund N, Wieloch T et al (2021) Plasticity-enhancing effects of levodopa treatment after stroke

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Adjustments occur based on recovery speed, pain levels, and functional movement (range of motion, strength return)

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Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

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