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NR : Not reported Design In the obesity trial, 338 participants (mean age 48 years, 48% women, mean BMI 37.3 kg/m 2 ) were randomised (2:1:1:1:1:2:2) to retatrutide 1 mg, 4 mg (titration), 4 mg (no titration), 8 mg (slow titration), 8 mg (fast titration), 12 mg or placebo over 48 weeks [45]

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With the progression of degeneration, the imbalance between catabolism and anabolism and the continuous deterioration of the microenvironment may further inhibit the activity of stem/progenitor cells, placing higher demands on treatment strategies

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