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It has been promoted variously as a weight loss supplement, as an aid to muscle and cartilage repair, and a treatment for osteoarthritis by its manufacturers

Maruyama T

The underlying mechanism involves the suppression of the NF-B signaling pathway, which plays a crucial role in inflammation and keratinocyte proliferation associated with PsO

According to the above studies, inhibiting GPX4 to induce ferroptosis in renal cancer cells may be a breakthrough for future applications in cancer therapeutics

Nature Microbiology

Esculetin improved lipid metabolism in FFA-treated primary hepatocytes by decreasing expression of Srebp1c and increasing expression of Ppar- as well as reducing lipid accumulation