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or preparation, review, or approval of the manuscript Acknowledgments: The authors thank Sameer Desale, MS, and Mihriye Mete, PhD, of MedStar Health Research Institute, Baltimore, Maryland, for statistical support and Lyn Camire, MA, ELS, of MedStar Union Memorial Hospital, Baltimore, Maryland, for editorial assistance

The start-up meeting took place in Barcelona, Spain in February 2017, followed by one meeting of the subgroup coordinators in Heidelberg, Germany in November 2017 and a face-to-face meeting for the whole guideline group in Athens, Greece in September 2018 (at the meeting of the Society for the Study of Inborn Errors of Metabolism (SSIEM))