Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg OC(=O)C(F)(F)F

OC(=O)C(F)(F)F

Sci Transl Med 2021

871 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCN2C(=O)C=CC2=O)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

The conjugates of TMR C2 maleimides have the identical excitation and emission wavelengths at 544/572 nm to those of tetramethylrhodamine maleimides or iodoacetamide

Product Name N'-Formylkynurenine Synonyms CAS Number 1022-31-7 Related CAS Molecular Formula C11H12N2O4 Molecular Weight 236

Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg OC(=O)C(F)(F)FSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I