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Downregulation of lncRNA ITSN1-2 Correlates With Decreased Disease Risk and Activity of Rheumatoid Arthritis (RA), and Reduces RA Fibroblast-Like Synoviocytes Proliferation and Inflammation via Inhibiting NOD2/RIP2 Signaling Pathway

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These accumulated lipids release free fatty acids and pro-inflammatory cytokines, leading to systemic, low-grade, subclinical chronic inflammation associated with insulin resistance, exacerbating ectopic fat deposition and metabolic dysfunction, ultimately affecting renal, hepatic, cardiovascular, and endocrine health [7,9,10,11,12]