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In addition, the prognostic assays described herein can be used to determine whether an agent (e.g., agonist, antagonist, peptidomimetic, polypeptide, peptide, nucleic acid, small molecule, or other drug candidate) can be administered to a subject to treat a disease or disorder associated with aberrant biomarker expression or activity

He and his colleagues confirmed that the extra glutathione in the treated mice caused levels of RhoA to increase in their metastatic tumors

Furthermore, leptin potentiates hepatic inflammation through TNF- release from Kupffer cells and stimulates CCL2 production in HSCs [227]

USA 103 , 1274712752 (2006)

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