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doi:10.1111/j.1365-313X.2004.02269.x

revealed that HK2 enhances glycolysis through the ROS/PI3K/AKT pathway, and inhibiting HK2 lowered ROS levels, improving the efficacy of cancer treatments (168)

Through simulation of the viral biomass reaction, important factors influencing viral replication can be identified, such as essential enzymes or the availability of specific nutrients 17