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The elevated levels of proinflammatory cytokines and chemokines such as tumour necrosis factor (TNF)-, interleukin 1 (IL-1), IL-6, IL-8 [2,7] and others indicate the cytokine storm plays a central role in the immunopathology of COVID-19, but the primary source or the exact virological mechanisms behind it have not been identified yet [8]

2 Fernandez-Checa J, Lu SC, Ookhtens M, DeLeve L, Runnegar M, Yoshida H, Saiki H, Kannan R, Garcia-Ruiz C, Kuhlenkamp JF, Kaplowitz N: The regulation of hepatic glutathione

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For each skin section, an area just beneath the epidermis or crust formation was randomly selected, followed by four consecutive areas moving towards the deep dermis