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A 2023 systematic review concluded benefits are promising but more, larger trials are needed

Thus, in the adipose tissue, physiological IGF-1 concentrations are not effective in stimulating changes in lipid synthesis or lipolysis, only at high concentrations is capable of stimulating glucose transport via the insulin receptor [182]

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Hybrid receptor activation may produce metabolic effects (glucose uptake, anti-lipolysis) that are not strictly part of IGF1R-mediated anabolism

The most notable clinical finding of this case is the dramatic and rapid therapeutic response with apremilast, which is faster than the efficacy reported in existing literature ( Unlike cyclosporine and methotrexate, apremilast does not cause significant immunosuppression or end-organ toxicity