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16 , e1009260 (2020)

Lane 1: human HepG2 whole cell lysates, Lane 2: human MCF-7 whole cell lysates, Lane 3: human RT4 whole cell lysates, Lane 4: monkey COS-7 whole cell lysates, Lane 5: rat kidney tissue lysates, Lane 6: rat testis tissue lysates, Lane 7: mouse kidney tissue lysates

The resulting accumulation of lipid ROS, coupled with the ability of ONOO to directly initiate lipid peroxidation, creates a vicious cycle of membrane damage

Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver

SLC25A32 transports THF into mitochondria to support one-carbon (1 C) metabolism that converts serine into formate, which is then exported into the cytosol for de novo purine biosynthesis (Fig