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Muscle is more vascularized than SC tissue and the absorption of drugs is faster after an IM injection, which leads to modified response as compared to that obtained after SC injection

The Switching Protocol If switching from semaglutide to tirzepatide: Take your last dose of semaglutide as scheduled Wait one week (your normal injection day) Start tirzepatide at the initial dose recommended by your provider Follow the prescribed titration schedule Start tirzepatide at the dose recommended by your provider, even if you were on a higher dose of semaglutide

No evidence of an additive inhibitory feeding effect following PP and PYY 3-36 administration