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While the protected methyl (2 S ,4 S )-4-hydroxypyroglutamate formed a basis for the construction of the alkaloid hemerocallisamine skeleton [37], its tert -butyl counterpart was used as a starting material in a multistep synthesis of a functionalized exo -methylenecyclopentane skeleton as an entecavir intermediate [116]

Further, various toxins and medications may also result in free radical reactions, including types of cancer chemotherapy

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Aging Cell 18 (6), e13031

A summary of the targets and associated molecules or complexes of PARP-1 in liver diseases is presented in Table I

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