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Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

Evidence from animal studies suggests that the effects of GCs on LTP and memory follow an inverted U-shaped dose-response relationship, with moderate physiological levels supporting synaptic plasticity and memory consolidation, whereas both insufficient and excessive GC exposure are associated with impairment (Pavlides et al., 2002

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Birnkrant et al 2018): Burns or major trauma (2472 hours post-injury) Neuromuscular disorders Myopathies Acute narrow-angle glaucoma or penetrating eye injury Side Effects Malignant hyperthermia (rare but fatal risk) Hyperkalemia (can be life-threatening) Risk of: Cardiac arrest Rhabdomyolysis Cardiac arrhythmias (bradycardia or tachycardia) Muscle pain (due to fasciculations) Increased intragastric pressure aspiration risk Increased intraocular pressure (contraindicated in glaucoma) Figure 3

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