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In addition, melatonin has the dual capability of targeting receptor-independent and receptor-dependent processes

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Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility No evidence of carcinogenic potential was obtained in an 88-week carcinogenicity study of donepezil conducted in mice at oral doses up to 180 mg/kg/day (approximately 40 times the maximum recommended human dose [MRHD] of 23 mg/day on a mg/m2 basis), or in a 104-week carcinogenicity study in rats at oral doses up to 30 mg/kg/day (approximately 13 times the MRHD on a mg/m2 basis)