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The validated path comes first: sleep hygiene, cognitive behavioral therapy for insomnia (CBT-I), evaluation for an underlying sleep disorder, and established interventions such as melatonin where appropriate

Telomerase the ribonucleoprotein enzyme complex that maintains telomere length is silenced in most human somatic cells, contributing to the progressive telomere shortening that drives replicative senescence

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Kristrom, B., Jansson, C., Rosberg, S