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H., Sodickson, D

Loss-of-function missense mutations as well as single nucleotide polymorphisms in the genes encoding K ir 4.1 and AQP4 (which is selectively astroglial and operates in concert with K ir 4.1) are linked to epilepsy in humans

doi: 10.1038/s41531-024-00724-z 36

103 In one randomized clinical trial in 70 volunteers with chronic tinnitus, both 3 mg of melatonin daily and a standard dose of sertraline (Zoloft) (an antidepressant medication) for three months reduced tinnitus severity, but melatonin was more effective