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Taken together, our findings suggest that Cilengitide treatment can block tumor progression caused by POSTN-induced lipid accumulation under HFD, and the combination of AKT/ERK inhibitors is more effective, suggesting that this treatment approach is expected to become a new strategy for the targeted therapy of obesity-related CRC

elegans revealed extended life- and health-span independently of other mechanisms (Jenkins et al., 2020)

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