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Systemic inflammatory responses, as well as superoxide, nitric oxide, and peroxynitrite could impair cardiac CPT1 activity in vivo and in vitro , thus leading to myocardial dysfunction (Fukumoto et al., 2002)

FIGURE 5 3.6 CPT1A protects against SAP in mice by inhibiting the NLRP3/GSDMD-mediated pyroptosis signalling pathway To investigate the protective mechanism of CPT1A in SAP, we assessed the expression changes of proteins involved in NLRP3 inflammasome activation